Alfa-taxilina
Alfa-taxilina
| |
| Identificadores | |
| Símbolo | TXLNA ; IL14; TXLN |
| Entrez | 200081 |
| OMIM | |
| RefSeq | NP_787048 |
| UniProt | P40222 |
| Outros datos | |
| Locus | Cr. 1 :(32.65 – 32.66 Mb) |
Alfa-taxilina (TXLNA) é o nome que se lle dá actualmente á proteína reguladora tamén coñecida como interleucina-14 (IL-14 ou IL14) ou factor de crecemento das células B de alto peso molecular (HMW-BCGF), que nos humanos está codificada no xene TXLNA do cromosoma 1.[1][2][3]
A alfa-taxilina ou IL-14 é unha citocina que controla o crecemento e a proliferación de células B tanto normais coma cancerosas.[4][5] A alfa-taxilina ou IL-14 induce a proliferación de células B, inhibe a secreción de anticorpos por estas células, e expande os subgrupos de células B seleccionados. Esta interleucina é producida principalmente polas células T e certas células B malignas.
Xene
[editar | editar a fonte]No rato prodúcense dous transcritos distintos das febras opostas do xene il14 que se denominan IL-14α e IL-14β.[6]
Notas
[editar | editar a fonte]- ↑ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. PMID 15184072. doi:10.1016/j.bbrc.2004.05.073.
- ↑ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. PMID 14623251. doi:10.1016/j.bbrc.2003.10.069.
- ↑ "Entrez Gene: TXLNA taxilin alpha".
- ↑ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. PMC 46922. PMID 8327514. doi:10.1073/pnas.90.13.6330.
- ↑ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells 8 (1): 17–28. PMID 12558796. doi:10.1046/j.1365-2443.2003.00612.x.
- ↑ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. PMID 17015757.
Véxase tamén
[editar | editar a fonte]Outros artigos
[editar | editar a fonte]Bibliografía
[editar | editar a fonte]- Ambrus JL, Pippin J, Joseph A; et al. (1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. PMC 46922. PMID 8327514. doi:10.1073/pnas.90.13.6330.
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.
- Ambrus JL, Pippin J, Joseph A; et al. (1996). "Identification of a cDNA for a human high molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 8154. PMC 38894. PMID 8755619.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. PMC 139146. PMID 9110174. doi:10.1101/gr.7.4.353.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948. PMID 11076863. doi:10.1101/gr.143000.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072. PMID 11230166. doi:10.1101/gr.GR1547R.
- Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. PMC 1083732. PMID 11256614. doi:10.1093/embo-reports/kvd058.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Nogami S, Satoh S, Nakano M; et al. (2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells 8 (1): 17–28. PMID 12558796. doi:10.1046/j.1365-2443.2003.00612.x.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. PMID 14743216. doi:10.1038/ncb1086.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
- Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930. PMID 15489336. doi:10.1101/gr.2576704.
- Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501. PMID 16381901. doi:10.1093/nar/gkj139.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
- Shen L, Zhang C, Wang T; et al. (2007). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. PMID 17015757.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948. PMID 17353931. doi:10.1038/msb4100134.
