Dinámica de virus

A dinámica de virus é o campo da Biomatemática dedicado á descrición do comportamento dos virus.^[1] Os modelos matemáticos empregados reflicten os cambios da poboación de células afectada ao longo do tempo, así como a competición entre distintas cepas víricas e o efecto da resposta inmunitaria.

Orixinalmente, a dinámica vírica baseábase nos modelos preexistentes para epidemias e na actualidade manteñen unha semellanza considerable no que ás ferramentas matemáticas empregadas se refire, como por exemplo o uso do número básico de reprodución. Porén, existen diferenzas noutros aspectos, entre as que destaca a disparidade da escala considerada: dentro dun individuo fronte a entre individuos, respectivamente.

Un campo de aplicación frecuente desta disciplina é o estudo do VIH,^[1]^[2] así como as hepatites B,^[3]^[4] e C^[5]^[6]

Notas

↑ ^1,0 ^1,1 Nowak, Martin; May, Robert (2001). Virus Dynamics: mathematical principles of immunology and virology.
↑ Perelson, Alan S; Ribeiro, Ruy M (2013). "Modeling the within-host dynamics of HIV infection". BMC Biology 11 (1): 96. doi:10.1186/1741-7007-11-96.
↑ Nowak, MA; Bonhoeffer, S; Hill, AM; Boehme, R; Thomas, HC; McDade, H (1996). "Viral dynamics in hepatitis B virus infection". Proceedings of the National Academy of Sciences 93: 4398–4402. doi:10.1073/pnas.93.9.4398.
↑ Ciupe, SM; Ribeiro, RM; Nelson, PW; Perelson, AS (2007). "Modeling the mechanisms of acute hepatitis B virus infection". Journal of Theoretical Biology 247 (1): 23–35. doi:10.1016/j.jtbi.2007.02.017.
↑ Neumann, A; Lam, NP; Dahari, H; Gretch, DR; Wiley, TE; Layden, TJ; Perelson, AS (1998). "Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy". Science 282 (5386): 103–107. doi:10.1126/science.282.5386.103.
↑ Chatterjee, A; Smith, PF; Perelson, AS (2013). "Hepatitis C Viral Kinetics: The Past, Present, and Future". Clinics in Liver Disease 17 (1): 13–26. doi:10.1016/j.cld.2012.09.003.

Ligazóns externas

Viral Dynamics Mathematical Modeling Training, Center for AIDS Research, University of Washington

[VDbook-1] 1,0 ^1,1 Nowak, Martin; May, Robert (2001). Virus Dynamics: mathematical principles of immunology and virology.

[2] Perelson, Alan S; Ribeiro, Ruy M (2013). "Modeling the within-host dynamics of HIV infection". BMC Biology 11 (1): 96. doi:10.1186/1741-7007-11-96.

[3] Nowak, MA; Bonhoeffer, S; Hill, AM; Boehme, R; Thomas, HC; McDade, H (1996). "Viral dynamics in hepatitis B virus infection". Proceedings of the National Academy of Sciences 93: 4398–4402. doi:10.1073/pnas.93.9.4398.

[4] Ciupe, SM; Ribeiro, RM; Nelson, PW; Perelson, AS (2007). "Modeling the mechanisms of acute hepatitis B virus infection". Journal of Theoretical Biology 247 (1): 23–35. doi:10.1016/j.jtbi.2007.02.017.

[5] Neumann, A; Lam, NP; Dahari, H; Gretch, DR; Wiley, TE; Layden, TJ; Perelson, AS (1998). "Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy". Science 282 (5386): 103–107. doi:10.1126/science.282.5386.103.

[6] Chatterjee, A; Smith, PF; Perelson, AS (2013). "Hepatitis C Viral Kinetics: The Past, Present, and Future". Clinics in Liver Disease 17 (1): 13–26. doi:10.1016/j.cld.2012.09.003.

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