Gliceraldehido-3-fosfato deshidroxenase espermatoxénica
- Véxase tamén: GAPDH e gliceraldehido-3-fosfato deshidroxenase (homónimos).
A gliceraldehido-3-fosfato deshidroxenase espermatoxénica[1] ou gliceraldehido-3-fosfato deshidroxenase específica de testículo (abreviada como GAPDHS ou GAPDH2) é un encima que nos humanos está codificado polo xene GAPDHS do cromosoma 19 humano, que se expresa de xeito específico nas células espermatoxénicas dos testículos fundamentalmente, e é distinto do encima glicolítico similar atopado nas células somáticas.[2][3]
Este encima da familia das gliceraldehido-3-fosfato deshidroxenases xoga un importante papel no metabolismo. Como o seu encima similar das células somáticas, este encima específico do esperma funciona dependendo da nicotinamida adenina dinucleótido para quitar hidróxeno e engadir fosfato ao gliceraldehido 3-fosfato para formar así 1,3-bisfosfoglicerato. Durante a espermatoxénese, este encima pode ter un importante papel na regulación do cambio entre diferentes vías metabólicas produtoras de enerxía, e é necesario para a motilidade dos espermatozoides e a fertilidade masculina.[3]
Notas
[editar | editar a fonte]- ↑ OMIM GAPDHS
- ↑ Welch JE, Brown PL, O'Brien DA, Magyar PL, Bunch DO, Mori C, Eddy EM (2000). "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells". J Androl 21 (2): 328–38. PMID 10714828.
- ↑ 3,0 3,1 "Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic".
Véxase tamén
[editar | editar a fonte]Outros artigos
[editar | editar a fonte]- GAPDH de células somáticas
Bibliografía
[editar | editar a fonte]- Cooper TG, Yeung CH (2001). "Approaches to post-testicular contraception.". Asian J. Androl. 1 (1–2): 29–36. PMID 11225901.
- Benham FJ, Povey S (1989). "Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations". Genomics 5 (2): 209–14. PMID 2793178. doi:10.1016/0888-7543(89)90048-7.
- Peterson RN, Freund M (1973). "Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa" (PDF). Biol. Reprod. 8 (3): 350–7. PMID 4349855. Arquivado dende o orixinal (PDF) o 23 de setembro de 2015. Consultado o 14 de decembro de 2013.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Westhoff D, Kamp G (1997). "Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa". J. Cell. Sci. 110 (15): 1821–9. PMID 9264469.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S (2000). "L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa". Mol. Hum. Reprod. 6 (2): 127–36. PMID 10655454. doi:10.1093/molehr/6.2.127.
- Bone W, Jones AR, Morin C; et al. (2001). "Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro". J. Androl. 22 (3): 464–70. PMID 11330647.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. PMID 15057824. doi:10.1038/nature02399.
- Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. PMC 515316. PMID 15342556. doi:10.1101/gr.2435604.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
- Li Y, Nowotny P, Holmans P; et al. (2004). "Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15688–93. PMC 524264. PMID 15507493. doi:10.1073/pnas.0403535101.
- Kodama R, Kondo T, Yokote H; et al. (2006). "Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)". Genes Cells 10 (12): 1211–9. PMID 16324157. doi:10.1111/j.1365-2443.2005.00911.x.
- Welch JE, Barbee RR, Magyar PL; et al. (2007). "Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis". Mol. Reprod. Dev. 73 (8): 1052–60. PMID 16700075. doi:10.1002/mrd.20235.
- Yatsenko AN, Roy A, Chen R; et al. (2007). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Hum. Mol. Genet. 15 (23): 3411–9. PMID 17047026. doi:10.1093/hmg/ddl417.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948. PMID 17353931. doi:10.1038/msb4100134.