Factor de crecemento de queratinocitos
(Redirección desde «KGF»)
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| PDB 1qqk | |
Factor de crecemento de queratinocitos
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| Identificadores | |
| Símbolo | FGF7 |
| Símbolos alt. | HBGF-7, KGF, fibroblast growth factor 7 |
| Entrez | 2252 |
| RefSeq | NP_002000 |
| UniProt | P21781 |
| Outros datos | |
| Locus | Cr. 15 15q21.2:(49.42 – 49.49 Mb) |
O factor de crecemento de queratinocitos ou KGF (do inglés keratinocyte growth factor), tamén coñecido como FGF7, é un factor de crecemento presente na fase de epitelización da curación de feridas. Nesta fase, os queratinocitos cobren a ferida, formando o epitelio. Está codificado no xene FGF7 do cromosoma 15 humano.[1][2][3]
O KGF é unha pequena molécula de sinalización que se une ao receptor do factor de crecemento de fibroblastos 2b (FGFR2b).[4] Para que ocorra a sinalización, requírese a formación dun dímero entre dous complexos FGF:FGFR que están ligados por unha molécula de heparina.
O KGF pertence á familia do FGF. Coñécense 23 FGF, e 4 receptores de FGF. A unión de FGF:FGFR é complexa e está regulada por diversos mecanismos de maneira específica de tecidos.
O FGF10 tamén se coñece como "factor de crecemento de queratinocitos 2".[5]
Función
[editar | editar a fonte]A proteína codificada polo xene FGF7 é un membro da familia do factor de crecemento de fibroblastos (FGF). Os membros da familia de FGF posúen amplas actividades mitoxénicas e de supervivencia celular e están implicados en diversos procesos biolóxicos, como o desenvolvemento embrionario, crecemento celular, morfoxénese, reparación de tecidos, crecemento e invasión de tumores. Esta proteína é un factor de crecemento específico de células epiteliais potente, cuxa actividade mitoxénica é exhibida predominantemente en queratinocitos pero non en fibroblastos e céllas endoteliais. Estudos feitos en ratos e ratas homólogas deste xene atoparon funcións na morfoxénese de epitelio, reepitelialización de feridas, desenvolvemento do pelo e organoxénese temperán dos pulmóns.[3]
Interaccións
[editar | editar a fonte]O FGF7 presenta interaccións co perlecán.[6]
Notas
[editar | editar a fonte]- ↑ Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome 6 (3): 196–7. PMID 7749227. doi:10.1007/BF00293012.
- ↑ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America 89 (19): 9287–91. PMC 50111. PMID 1409637. doi:10.1073/pnas.89.19.9287.
- ↑ 3,0 3,1 "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)".
- ↑ Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). Maas S, ed. "Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells". PLoS ONE 3 (6): e2528. PMC 2424182. PMID 18575591. doi:10.1371/journal.pone.0002528.
- ↑ "iHOP - Information Hyperlinked over Proteins [ FGF10 ]". Arquivado dende o orixinal o 14 de febreiro de 2012.
- ↑ Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry 275 (10): 7095–100. PMID 10702276. doi:10.1074/jbc.275.10.7095.
Véxase tamén
[editar | editar a fonte]Outros artigos
[editar | editar a fonte]Bibliografía
[editar | editar a fonte]- Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S (Dec 2000). "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings 5 (1): 34–9. PMID 11147673. doi:10.1046/j.1087-0024.2000.00009.x.
- Ware LB, Matthay MA (May 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology 282 (5): L924–40. PMID 11943656. doi:10.1152/ajplung.00439.2001.
- Finch PW, Rubin JS (2004). "Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair". Advances in Cancer Research. Advances in Cancer Research 91: 69–136. ISBN 978-0-12-006691-9. PMID 15327889. doi:10.1016/S0065-230X(04)91003-2.
- Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA (Dec 1992). "Expression cloning of a human dual-specificity phosphatase". Proceedings of the National Academy of Sciences of the United States of America 89 (24): 12170–4. PMC 50720. PMID 1281549. doi:10.1073/pnas.89.24.12170.
- Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS (1992). "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences 638: 62–77. PMID 1664700. doi:10.1111/j.1749-6632.1991.tb49018.x.
- Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (Aug 1989). "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science 245 (4919): 752–5. PMID 2475908. doi:10.1126/science.2475908.
- Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (Feb 1989). "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America 86 (3): 802–6. PMC 286565. PMID 2915979. doi:10.1073/pnas.86.3.802.
- Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR (Mar 1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry 268 (8): 5388–94. PMID 7680645.
- Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (Aug 1993). "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology 13 (8): 4513–22. PMC 360063. PMID 7687739.
- Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT (Nov 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science 266 (5186): 819–22. PMID 7973639. doi:10.1126/science.7973639.
- Wilson SE, Walker JW, Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science 34 (8): 2544–61. PMID 8392040.
- Guo L, Degenstein L, Fuchs E (Jan 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development 10 (2): 165–75. PMID 8566750. doi:10.1101/gad.10.2.165.
- Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry 271 (25): 15292–7. PMID 8663044. doi:10.1074/jbc.271.25.15292.
- Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK (Oct 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development 122 (10): 3107–15. PMID 8898224.
- Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC (Oct 1997). "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America 94 (21): 11461–5. PMC 23506. PMID 9326632. doi:10.1073/pnas.94.21.11461.
- Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS (Dec 1997). "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology 173 (3): 380–6. PMID 9369951. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G.
- Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (Oct 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology 107 (10 Pt 1): 885–90. PMID 9794620.
- Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry 275 (10): 7095–100. PMID 10702276. doi:10.1074/jbc.275.10.7095.
