Receptor de interleucina 8, beta

Receptor (motivo C-X-C) 2 de quimiocinas (Chemokine (C-X-C motif) receptor 2)
Identificadores
Símbolo	CXCR2 ; CD182; CDw128b; CMKAR2; IL8R2; IL8RB
Entrez	3579
HUGO	6027
OMIM	146928
RefSeq	NP_001161770
UniProt	P25025
Outros datos
Locus	Cr. 2 :(218.99 – 219 Mb)

O receptor de interleucina 8, beta é un receptor de quimiocinas, que se coñece tamén coas siglas IL8RB, CD182, CXCR2, e CXCR2 (receptor (motivo C-X-C) 2 de quimiocinas) é agora o nome recomendado polo Comité de Nomenclatura de Receptores e Clasificación de Fármacos da IUPHAR.^[1]

Función

A proteína codificada por este xene é membro da familia do receptor acoplado á proteína G. Esta proteína é un receptor da interleucina 8 (IL8). Únese á IL8 con alta afinidade, e transduce o sinal por medio dun sistema de segundo mensaxeiro activado pola proteína G (G_i/o-acoplado^[2]). Este receptor tamén se une á quimiocina (motivo C-X-C) ligando 1 (CXCL1/MGSA), unha proteína con actividade de estimulación do crecemento de melanomas, e é un compoñente principal requirido para o crecemento de células de melanoma dependente de soro. Ademais, únese a ligandos como CXCL2, CXCL3, e CXCL5.

Este receptor é un mediador na migración de neutrófilos aos sitios de inflamación. Os efectos anxioxénicos do IL8 en células endotelias microvasculares intestinais tamén son mediados por este receptor. Os estudos con ratos knockout indicaron que este receptor controla a posición de precursores dos oligodendrocitos na medula espiñal en desenvolvemento ao deter a súa migración. O xene IL8RB, xunto con IL8RA, que codifica outro receptor de IL8 de alta afinidade, e o IL8RBP, que é un pseudoxene de IL8RB, forman un cluster de xenes nunha rexión mapada no cromosoma 2q33-q36. Existen variantes de splicing.^[3] O xene IL8RB contén 3 exóns e dous intróns.

As mutacións en CXCR2 causan doenzas hematolóxicas.^[4]

Senescencia

Os estudos knock-down que implican ao receptor de quimiocinas CXCR2 alivia tanto a senescencia inducida por oncoxenes coma a replicativa e diminúe a resposta aos danos no ADN. Ademais, a expresión ectópica de CXCR2 dá lugar a unha senescencia prematura por medio dun mecanismo dependente de p53.^[5]

Notas

↑ Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (November 1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics 14 (3): 685–91. PMID 1427896. doi:10.1016/S0888-7543(05)80169-7.
↑ "Entry in: gpDB, database of GPCRs, G-proteins, Effectors and their interactions". Consultado o 3 October 2012.
↑ "Entrez Gene: IL8RB interleukin 8 receptor, beta".
↑ Jump up ^ Auer, P. L.; Teumer, A; Schick, U; O'Shaughnessy, A; Lo, K. S.; Chami, N; Carlson, C; De Denus, S; Dubé, M. P.; Haessler, J; Jackson, R. D.; Kooperberg, C; Perreault, L. P.; Nauck, M; Peters, U; Rioux, J. D.; Schmidt, F; Turcot, V; Völker, U; Völzke, H; Greinacher, A; Hsu, L; Tardif, J. C.; Diaz, G. A.; Reiner, A. P.; Lettre, G (2014). "Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits". Nature Genetics 46 (6): 629–34. doi:10.1038/ng.2962. PMID 24777453.
↑ Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. (June 2008). "Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence.". Cell. 133 (6): 1006–18. PMID 18555777. doi:10.1016/j.cell.2008.03.038.

Véxase tamén

Outros artigos

References

Bibliografía

Brandt E, Ludwig A, Petersen F, Flad HD (2001). "Platelet-derived CXC chemokines: old players in new games.". Immunol. Rev. 177: 204–16. PMID 11138777. doi:10.1034/j.1600-065X.2000.17705.x.
Robertson MJ (2002). "Role of chemokines in the biology of natural killer cells.". J. Leukoc. Biol. 71 (2): 173–83. PMID 11818437.
Ahuja SK, Ozçelik T, Milatovitch A; et al. (1993). "Molecular evolution of the human interleukin-8 receptor gene cluster.". Nat. Genet. 2 (1): 31–6. PMID 1303245. doi:10.1038/ng0992-31.
Lee J, Horuk R, Rice GC; et al. (1992). "Characterization of two high affinity human interleukin-8 receptors.". J. Biol. Chem. 267 (23): 16283–7. PMID 1379593.
Morris SW, Nelson N, Valentine MB; et al. (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.". Genomics 14 (3): 685–91. PMID 1427896. doi:10.1016/S0888-7543(05)80169-7.
Holmes WE, Lee J, Kuang WJ; et al. (1991). "Structure and functional expression of a human interleukin-8 receptor.". Science 253 (5025): 1278–80. PMID 1840701. doi:10.1126/science.1840701.
Murphy PM, Tiffany HL (1991). "Cloning of complementary DNA encoding a functional human interleukin-8 receptor.". Science 253 (5025): 1280–3. PMID 1891716. doi:10.1126/science.1891716.
Sprenger H, Lloyd AR, Lautens LL; et al. (1994). "Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.". J. Biol. Chem. 269 (15): 11065–72. PMID 7512557.
Morohashi H, Miyawaki T, Nomura H; et al. (1995). "Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.". J. Leukoc. Biol. 57 (1): 180–7. PMID 7829970.
Ahuja SK, Shetty A, Tiffany HL, Murphy PM (1994). "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.". J. Biol. Chem. 269 (42): 26381–9. PMID 7929358.
Cacalano G, Lee J, Kikly K; et al. (1994). "Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.". Science 265 (5172): 682–4. PMID 8036519. doi:10.1126/science.8036519.
Harada A, Kuno K, Nomura H; et al. (1994). "Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor.". Gene 142 (2): 297–300. PMID 8194768. doi:10.1016/0378-1119(94)90278-X.
Schnitzel W, Monschein U, Besemer J (1994). "Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B.". J. Leukoc. Biol. 55 (6): 763–70. PMID 8195702.
Mueller SG, Schraw WP, Richmond A (1994). "Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells.". J. Biol. Chem. 269 (3): 1973–80. PMID 8294449.
Wu D, LaRosa GJ, Simon MI (1993). "G protein-coupled signal transduction pathways for interleukin-8.". Science 261 (5117): 101–3. PMID 8316840. doi:10.1126/science.8316840.
Cerretti DP, Kozlosky CJ, Vanden Bos T; et al. (1993). "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.". Mol. Immunol. 30 (4): 359–67. PMID 8384312. doi:10.1016/0161-5890(93)90065-J.
Ahuja SK, Lee JC, Murphy PM (1996). "CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. Determinants of high affinity binding and receptor activation are distinct.". J. Biol. Chem. 271 (1): 225–32. PMID 8550564. doi:10.1074/jbc.271.1.225.
Hammond ME, Shyamala V, Siani MA; et al. (1996). "Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket.". J. Biol. Chem. 271 (14): 8228–35. PMID 8626516. doi:10.1074/jbc.271.14.8228.
Damaj BB, McColl SR, Mahana W; et al. (1996). "Physical association of Gi2alpha with interleukin-8 receptors.". J. Biol. Chem. 271 (22): 12783–9. PMID 8662698. doi:10.1074/jbc.271.22.12783.
Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor.". J. Biol. Chem. 271 (34): 20545–50. PMID 8702798. doi:10.1074/jbc.271.34.20545.

Ligazóns externas

CD182 Antigen Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA.
"Chemokine Receptors: CXCR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arquivado dende o orixinal o 15 de xuño de 2015.

[pmid1427896-1] Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (November 1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics 14 (3): 685–91. PMID 1427896. doi:10.1016/S0888-7543(05)80169-7.

[2] "Entry in: gpDB, database of GPCRs, G-proteins, Effectors and their interactions". Consultado o 3 October 2012.

[entrez-3] "Entrez Gene: IL8RB interleukin 8 receptor, beta".

[4] Jump up ^ Auer, P. L.; Teumer, A; Schick, U; O'Shaughnessy, A; Lo, K. S.; Chami, N; Carlson, C; De Denus, S; Dubé, M. P.; Haessler, J; Jackson, R. D.; Kooperberg, C; Perreault, L. P.; Nauck, M; Peters, U; Rioux, J. D.; Schmidt, F; Turcot, V; Völker, U; Völzke, H; Greinacher, A; Hsu, L; Tardif, J. C.; Diaz, G. A.; Reiner, A. P.; Lettre, G (2014). "Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits". Nature Genetics 46 (6): 629–34. doi:10.1038/ng.2962. PMID 24777453.

[pmid18555777-5] Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. (June 2008). "Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence.". Cell. 133 (6): 1006–18. PMID 18555777. doi:10.1016/j.cell.2008.03.038.

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