A proteína codificada neste xene é unha sialoglicoproteína e unha proteína de membrana de tipo I. É un membro da familia xénica dos xenes GYPA e GYPB. Esta proteína pode levar antíxenos do grupo sanguíneo M. Os tres xenes GYPA, GYPB e GYPE están dispostos en tándem no cromosoma 4. Este xene puido derivar dun xene ancestral común co xene GPB por medio de duplicación xénica. Neste xene describíronse dous transcritos variantes de empalme alternativo que codifican esta mesma proteína.[1]
Cartron JP, Rahuel C (1992). "Human erythrocyte glycophorins: protein and gene structure analyses". Transfusion Medicine Reviews6 (2): 63–92. PMID1591491. doi:10.1016/S0887-7963(92)70158-8.
Huang CH; Skov F; Daniels G; et al. (1992). "Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats". Blood80 (9): 2379–87. PMID1421409. doi:10.1182/blood.V80.9.2379.2379.
Vignal A, London J, Rahuel C, Cartron JP (1991). "Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E". Gene95 (2): 289–293. PMID2249783. doi:10.1016/0378-1119(90)90374-Z.
Kudo S, Fukuda M (1990). "Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction". J. Biol. Chem.265 (2): 1102–10. PMID2295603. doi:10.1016/S0021-9258(19)40164-6.
Vignal A; Rahuel C; London J; et al. (1990). "A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression". Eur. J. Biochem.191 (3): 619–625. PMID2390989. doi:10.1111/j.1432-1033.1990.tb19166.x.
Kudo S, Fukuda M (1994). "Contribution of gene conversion to the retention of the sequence for M blood group type determinant in glycophorin E gene". J. Biol. Chem.269 (37): 22969–74. PMID7521873. doi:10.1016/S0021-9258(17)31605-8.
Wang HY, Tang H, Shen CK, Wu CI (2004). "Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites". Mol. Biol. Evol.20 (11): 1795–1804. PMID12949139. doi:10.1093/molbev/msg185.