C1s (complemento)
(Redirección desde «C1s»)
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| PDB | Buscar ortólogos: PDBe, RCSB | ||
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| Nomenclatura | Outros nomes
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| Locus | Cr. 12 p13.31 | ||
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| RefSeq (ARNm) |
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| RefSeq (proteína) NCBI |
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| Localización (UCSC) |
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O compoñente do complemento 1s (EC 3.4.21.42) ou C1s é unha proteína que intervén no sistema do complemento do sistema inmunitario innato. C1s forma parte co complexo C1, xunto con C1q e C1r.[1][2][3][4] Nos humanos está codificado no xene C1S do cromosoma 12.[5]
O C1s corta os compoñentes C4 e C2 do complemento, o cal acaba por producir a convertase de C3 da vía clásica do complemento.
Notas
[editar | editar a fonte]- ↑ Sim RB (1981). "The human complement system serine proteases and their proenzymes". Proteolytic Enzymes, Part C. Methods in Enzymology. 80 Pt C. pp. 26–42. ISBN 9780121819804. PMID 6281620. doi:10.1016/s0076-6879(81)80006-7.
- ↑ Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (decembro de 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry 169 (3): 547–53. PMID 3500856. doi:10.1111/j.1432-1033.1987.tb13644.x.
- ↑ Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry 57: 321–47. PMID 3052276. doi:10.1146/annurev.bi.57.070188.001541.
- ↑ Skoog MT, Mehdi S, Wiseman JS, Bey P (xuño de 1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 996 (1–2): 89–94. PMID 2500154. doi:10.1016/0167-4838(89)90099-x.
- ↑ "Entrez Gene: C1S Complement component 1, s subcomponent".
Véxase tamén
[editar | editar a fonte]Outros artigos
[editar | editar a fonte]- C1q - outro membro do complexo C1
- C1r - outro membro do complexo C1
- MASP-2 - unha proteína similar a C1s, parte da vía da lectina
Bibliografía
[editar | editar a fonte]- Luo C, Thielens NM, Gagnon J, Gal P, Sarvari M, Tseng Y, Tosi M, Zavodszky P, Arlaud GJ, Schumaker VN (maio de 1992). "Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex". Biochemistry 31 (17): 4254–62. PMID 1533159. doi:10.1021/bi00132a015.
- Illy C, Thielens NM, Gagnon J, Arlaud GJ (xullo de 1991). "Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites". Biochemistry 30 (29): 7135–41. PMID 1854725. doi:10.1021/bi00243a014.
- Hess D, Schaller J, Rickli EE (marzo de 1991). "Identification of the disulfide bonds of human complement C1s". Biochemistry 30 (11): 2827–33. PMID 2007122. doi:10.1021/bi00225a014.
- Thielens NM, Van Dorsselaer A, Gagnon J, Arlaud GJ (abril de 1990). "Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region". Biochemistry 29 (14): 3570–8. PMID 2141278. doi:10.1021/bi00466a021.
- Busby TF, Ingham KC (maio de 1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q". Biochemistry 29 (19): 4613–8. PMID 2372546. doi:10.1021/bi00471a016.
- Kusumoto H, Hirosawa S, Salier JP, Hagen FS, Kurachi K (outubro de 1988). "Human genes for complement components C1r and C1s in a close tail-to-tail arrangement". Proceedings of the National Academy of Sciences of the United States of America 85 (19): 7307–11. Bibcode:1988PNAS...85.7307K. PMC 282175. PMID 2459702. doi:10.1073/pnas.85.19.7307.
- Katz Y, Strunk RC (March 1989). "Synthesis and regulation of C1 inhibitor in human skin fibroblasts". Journal of Immunology 142 (6): 2041–5. PMID 2537870. doi:10.4049/jimmunol.142.6.2041.
- Tosi M, Duponchel C, Meo T, Couture-Tosi E (agosto de 1989). "Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin". Journal of Molecular Biology 208 (4): 709–14. PMID 2553984. doi:10.1016/0022-2836(89)90161-7.
- Tosi M, Duponchel C, Meo T, Julier C (decembro de 1987). "Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr". Biochemistry 26 (26): 8516–24. PMID 2831944. doi:10.1021/bi00400a004.
- Nguyen VC, Tosi M, Gross MS, Cohen-Haguenauer O, Jegou-Foubert C, de Tand MF, Meo T, Frézal J (abril de 1988). "Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13". Human Genetics 78 (4): 363–8. PMID 2834284. doi:10.1007/BF00291737.
- Spycher SE, Nick H, Rickli EE (abril de 1986). "Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation". European Journal of Biochemistry 156 (1): 49–57. PMID 3007145. doi:10.1111/j.1432-1033.1986.tb09546.x.
- Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (decembro de 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry 169 (3): 547–53. PMID 3500856. doi:10.1111/j.1432-1033.1987.tb13644.x.
- Kauffman D, Hofmann T, Bennick A, Keller P (maio de 1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry 25 (9): 2387–92. PMID 3521730. doi:10.1021/bi00357a013.
- Bock SC, Skriver K, Nielsen E, Thøgersen HC, Wiman B, Donaldson VH, Eddy RL, Marrinan J, Radziejewska E, Huber R (xullo de 1986). "Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization". Biochemistry 25 (15): 4292–301. PMID 3756141. doi:10.1021/bi00363a018.
- Carter PE, Dunbar B, Fothergill JE (decem bro de 1983). "The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments". The Biochemical Journal 215 (3): 565–71. PMC 1152437. PMID 6362661. doi:10.1042/bj2150565.
- Nilsson T, Sjöholm I, Wiman B (setembro de 1983). "Structural and circular-dichroism studies on the interaction between human C1-esterase inhibitor and C1s". The Biochemical Journal 213 (3): 617–24. PMC 1152176. PMID 6604523. doi:10.1042/bj2130617.
- Rossi V, Gaboriaud C, Lacroix M, Ulrich J, Fontecilla-Camps JC, Gagnon J, Arlaud GJ (xuño de 1995). "Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling". Biochemistry 34 (22): 7311–21. PMID 7779774. doi:10.1021/bi00022a004.
- Bersch B, Hernandez JF, Marion D, Arlaud GJ (febreiro de 1998). "Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family". Biochemistry 37 (5): 1204–14. PMID 9477945. doi:10.1021/bi971851v.
- Endo Y, Takahashi M, Nakao M, Saiga H, Sekine H, Matsushita M, Nonaka M, Fujita T (novembro de 1998). "Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates". Journal of Immunology 161 (9): 4924–30. PMID 9794427. doi:10.4049/jimmunol.161.9.4924.
- Inoue N, Saito T, Masuda R, Suzuki Y, Ohtomi M, Sakiyama H (outubro de 1998). "Selective complement C1s deficiency caused by homozygous four-base deletion in the C1s gene". Human Genetics 103 (4): 415–8. PMID 9856483. doi:10.1007/s004390050843.
Ligazóns externas
[editar | editar a fonte]- Complement C1s Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA.
- Localización no xenoma humano de C1S e páxina con detalles sobre o xene C1S no UCSC Genome Browser.
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